|
KMID : 1134820200490020134
|
|
Journal of the Korean Society of Food Science and Nutrition
2020 Volume.49 No. 2 p.134 ~ p.140
|
|
|
Improvement Effects of Turnip Extracts (Brassica rapa L.) on TNF-α Induced Vascular Inflammation
|
|
Hwang Kyung-A
Hwang Yu-Jin
Hwang Hye-Jeong
Kim Young-Jun
Choe Jeong-Sook
Lee Sung-Hyun
Jang Hwan-Hee
|
|
|
Abstract
|
|
|
|
A high cholesterol diet, tobacco usage, and other negative life style elements are all factors that cause intravascular inflammation by interfering with the flow of blood and damaging vascular tissues. Recent cases of vascular diseases are gradually increasing due to these physical and chemical factors and the vascular inflammation persists, then the early symptoms of arteriosclerosis may occur. Turnip (Brassica rapa L.) is known to be a commonly consumed vegetable that has various physiological properties such as anti-inflammation and anti-cancer activities, among other activities. Therefore, this study investigated the anti-inflammatory effect of turnip extract in tumor necrosis factor-α (TNF-α) stimulated human umbilical vein endothelial cells (HUVECs). The mRNA and protein expressions of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) of the turnip extracts treated group, as compared to that of the TNF-α only treated group, were significantly inhibited at various concentration turnip extract treatment. The RNA of pro-inflammatory chemokines induced by the TNF-α expression were decreased by the turnip extract, and the turnip extract also inhibited NF-κB activity involved in inflammatory signaling. Nitric oxide (NO) was decreased by TNF-α treatment and significantly increased to 10.9 μM in the 100 μg/mL turnip extract treatment groups. Further, the mRNA and protein expressions of endothelial nitric oxide synthase (eNOS) were increased by the turnip extract in a dose-dependent manner. These results suggest the applicability of turnip extracts, because of their anti-inflammatory and vasodilatation functions, could be used to develop functional treatments to prevent the early onset of arteriosclerosis.
|
|
|
KEYWORD
|
|
|
turnip extracts, adhesion molecule, TNF-α, anti-inflammatory, HUVECs
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|